The Benefits of a Gel

Divigel® uses transdermal delivery to administer relief directly through your skin—no patches, no pills.

The gel medication is absorbed through your skin and goes directly into your bloodstream, avoiding circulation through the liver, so it can be used at lower doses than hormone pills2,8,9
A convenient and easy-to-use treatment approach that fits into your daily routine

Convenient Gel Formulation

Divigel® is an appealing gel formulation that’s convenient and discreet; it's very similar to the look and feel of hand sanitizer.

The clear gel is invisible and odorless when dry, so no one knows you’re using medication
It dries quickly, without a sticky residue; and once you have washed your hands, there is little risk of transfer from your skin to another person’s skin2
It’s skin-friendly: Less than 1% of women treated with Divigel® experienced application-site reactions2
Compared with all other gel or lotion estrogen therapy products, Divigel® requires a smaller amount of gel applied to a smaller area of skin2-5

Discreet and Easy to Use

Small packets are portable and easy to use at home and away.

Premeasured, individual-use foil packets to ensure precise, accurate dosing
Each foil packet contains a single day’s dose for convenient, consistent delivery of Divigel®
Store up to 14 foil packets in a handy Divigel® travel compact, available free when you click here

Important Safety Information for Patients

The following are not all the possible risks for Divigel®. Please read the full Patient Information leaflet and talk to your healthcare provider.

Estrogens increase the chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

Do not use estrogens, with or without progestins, to prevent heart disease, heart attacks, or strokes. Using estrogens, with or without progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots.

Do not use estrogens, with or without progestins, to prevent dementia. Using estrogens, with or without progestins, may increase your risk of dementia.

Do not use estrogen products, including Divigel®, if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, currently have or have had liver problems, are allergic to any Divigel® ingredients, or think you may be pregnant.

The most common side effects for all estrogen products are headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps and bloating, nausea and vomiting, and hair loss. The less common but serious side effects include breast cancer, cancer of the uterus, stroke, heart attack, blood clots, dementia, gallbladder disease, and ovarian cancer.

In Divigel® clinical trials, the most common side effects were inflammation of the nasal passages and pharynx, upper respiratory tract infection, vaginal yeast infection, breast tenderness and vaginal bleeding. Call your healthcare provider right away if you have any symptoms that concern you.

Estrogen products should be used at the lowest dose possible for your treatment and only as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment with Divigel®.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, call 1-800-654-2299.

*Once-daily dosing of estradiol.