Treatment Options

There are a number of options to consider when deciding how to manage your menopausal symptoms. These include:

Health and lifestyle changes1
Hormonal therapy, known as estrogen therapy (ET, estrogen alone) or hormone therapy (HT, estrogen with progesterone). Divigel® is one example of a bioidentical estrogen therapy for the treatment of uncomfortable hot flashes associated with menopause. Ask your healthcare professional if Divigel® is an appropriate treatment option for you
“Natural” remedies, such as herbal supplements1

No one choice is right for everyone. You’ll need to talk to your healthcare professional to determine what is right for you based on your lifestyle, medical history, and symptoms.

Health and Lifestyle

Being healthy is a good idea whether you have reached menopause or not. Here are a few reminders on what you can do to keep your body as healthy and strong as possible1:

Eat a well-balanced diet that includes calcium, fruits and vegetables, iron, and fiber (found in whole-grain breads, cereals, pasta, and rice)
Reduce your intake of foods that are high in fat—and avoid foods that contain trans fat
Drink plenty of water every day
Exercise regularly and try to maintain a healthy weight
Use sugar and salt in moderation
Limit your intake of alcohol beverages
Don’t smoke

Important Safety Information for Patients

The following are not all the possible risks for Divigel®. Please read the full Patient Information leaflet and talk to your healthcare provider.

Estrogens increase the chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

Do not use estrogens, with or without progestins, to prevent heart disease, heart attacks, or strokes. Using estrogens, with or without progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots.

Do not use estrogens, with or without progestins, to prevent dementia. Using estrogens, with or without progestins, may increase your risk of dementia.

Do not use estrogen products, including Divigel®, if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, currently have or have had liver problems, are allergic to any Divigel® ingredients, or think you may be pregnant.

The most common side effects for all estrogen products are headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps and bloating, nausea and vomiting, and hair loss. The less common but serious side effects include breast cancer, cancer of the uterus, stroke, heart attack, blood clots, dementia, gallbladder disease, and ovarian cancer.

In Divigel® clinical trials, the most common side effects were inflammation of the nasal passages and pharynx, upper respiratory tract infection, vaginal yeast infection, breast tenderness and vaginal bleeding. Call your healthcare provider right away if you have any symptoms that concern you.

Estrogen products should be used at the lowest dose possible for your treatment and only as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment with Divigel®.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, call 1-800-654-2299.