What to Expect

It’s important to apply Divigel® around the same time each day. This will help your body sustain the consistent levels of estrogen it needs to relieve your symptoms.2,11

In a clinical study, the highest dose of Divigel® significantly reduced the number of hot flashes after just 2 weeks vs placebo
Treatment with the lowest dose of Divigel® significantly reduced the number of hot flashes, including night sweats after 5 weeks vs placebo
While Divigel® may reduce hot flashes, including night sweats, in as little as 2 weeks, you can expect to see your symptoms improve even more over time, typically 8 to 12 weeks of treatment

For any estrogen therapy, it may take some time, but relief is worth the effort.

Is a Bioidentical Estrogen Like Divigel® Right for You?

Only you and your healthcare professional can decide if Divigel® is right for you. To help you start a conversation about estrogen therapy, ask your healthcare professional the following types of questions:

Given my personal and family medical history, is estrogen therapy appropriate for me?
How does Divigel® compare to a tablet or other form of estrogen therapy?
How long will I have to stay on Divigel®?
Can lifestyle changes also help my symptoms?

Divigel® is not right for everyone. Click here to learn more and talk to your doctor.

Important Safety Information for Patients

The following are not all the possible risks for Divigel®. Please read the full Patient Information leaflet and talk to your healthcare provider.

Estrogens increase the chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

Do not use estrogens, with or without progestins, to prevent heart disease, heart attacks, or strokes. Using estrogens, with or without progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots.

Do not use estrogens, with or without progestins, to prevent dementia. Using estrogens, with or without progestins, may increase your risk of dementia.

Do not use estrogen products, including Divigel®, if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, currently have or have had liver problems, are allergic to any Divigel® ingredients, or think you may be pregnant.

The most common side effects for all estrogen products are headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps and bloating, nausea and vomiting, and hair loss. The less common but serious side effects include breast cancer, cancer of the uterus, stroke, heart attack, blood clots, dementia, gallbladder disease, and ovarian cancer.

In Divigel® clinical trials, the most common side effects were inflammation of the nasal passages and pharynx, upper respiratory tract infection, vaginal yeast infection, breast tenderness and vaginal bleeding. Call your healthcare provider right away if you have any symptoms that concern you.

Estrogen products should be used at the lowest dose possible for your treatment and only as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment with Divigel®.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, call 1-800-654-2299.

*Once-daily dosing of estradiol.