Application that conveniently fits into your daily routine

You should apply Divigel® around the same time each day; make it easy to remember by applying Divigel® with your daily or evening personal care routine. Follow the once-daily application tips below for safe and effective use.

Preparation

Before applying Divigel®, make sure to wash and dry your hands. Next, cut or tear foil packet, and ensure that the application area is clean and dry.1

Application

Squeeze the entire contents of the foil packet onto clean and unbroken skin of your upper thigh; alternate between your left and right thigh each day. You will want to spread the gel on the thigh over an area about the size of a 5 x 7 photograph. It is not necessary to massage or rub in Divigel®.1


After use

When you are done applying Divigel®, dispose of the empty packet and wash your hands immediately to remove any remaining gel. Before dressing, be sure to allow the gel to dry completely. Make sure to wait at least 1 hour before bathing or swimming1

In case you miss a dose

 Determine when you are supposed to apply your next dose and follow the instructions below.




How to apply Divigel and important dosing information.

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Important Safety Information for Patients

The following are not all the possible risks for Divigel®. Please read the full Patient Information leaflet and talk to your healthcare provider.

Estrogens increase the chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

Do not use estrogens, with or without progestins, to prevent heart disease, heart attacks, or strokes. Using estrogens, with or without progestins, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots.

Do not use estrogens, with or without progestins, to prevent dementia. Using estrogens, with or without progestins, may increase your risk of dementia.

Do not use estrogen products, including Divigel®, if you have unusual vaginal bleeding, currently have or have had certain cancers, had a stroke or heart attack in the past year, currently have or have had blood clots, currently have or have had liver problems, are allergic to any Divigel® ingredients, or think you may be pregnant.

The most common side effects for all estrogen products are headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps and bloating, nausea and vomiting, and hair loss. The less common but serious side effects include breast cancer, cancer of the uterus, stroke, heart attack, blood clots, dementia, gallbladder disease, and ovarian cancer.

In Divigel® clinical trials, the most common side effects were inflammation of the nasal passages and pharynx, upper respiratory tract infection, vaginal yeast infection, breast tenderness and vaginal bleeding. Call your healthcare provider right away if you have any symptoms that concern you.

Estrogen products should be used at the lowest dose possible for your treatment and only as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment with Divigel®.

For more information, call 1-800-654-2299.

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